Celecoxib Blocks Vasculogenic Mimicry via an Off-Target Effect to Radiosensitize Lung Cancer Cells: An Experimental Study
The resistance to radiotherapy in lung cancer can be attributed to vasculogenic mimicry (VM) to some extent.Celecoxib (CXB), a selective inhibitor of cyclooxygenase-2 (COX-2), is reported as a radiosensitizer in non-small cell lung cancer (NSCLC).However, whether CXB can regulate VM formation via an off-target effect to radiosensitize NSCLC remains